Bertuzzi looks better when he doesn't have to deal with whatever Marner is trying to do these days. Historically, his success came alongside Dylan Larkin (LC) and Lucas Raymond (RW) who are both fairly direct and speedy players who carry the puck for the line. Bertuzzi-Matthews-Nylander fits the bill, as Matthews has shown he can adapt to just about any playstyle, and Nylander is Nylander. The key for Bertuzzi key is to just free up pucks into designated areas (back posts, bottom of the faceoff dots, high slot when available).
Domi is supposedly an offensive Kerfoot; what he lacks in off-puck management, he is supposed to have in speedy rush playmaking abilities. Keefe's system generally stresses attacking as a unit, save for the recent addition of springing Nylander, but creating a dedicated rush line would give opponents something different to contend with. Kampf is a decent centre for anchoring a rush line in that he is safe and can spring his wingers, but he doesn't add much offense himself unless the net is emptied. What would be very fun and worth a try is Domi-Kampf-Marner. Marner needs some time just playing N-S hockey to simplify his approach (he can E-W after getting set up in the OZ), and playing zippy hockey with his old London Knights buddy should be fun and silly. All three have pre-existing relationships outside of 5v5 with the Leafs.
Knies-Tavares-Jarnkrok puts a bit of burden on Jarnkrok and Knies to carry the puck through traps, but with a steady diet of OZ starts, they could wear down opponents significantly over the course of a game. They are all extremely annoying, stoic, and heavy players each with disgusting shots.
Gregor-Holmberg-Marlie is what's left. Reaves hasn't been specifically bad, but his lack of footspeed, regardless of his anticipation and instincts, put the Leafs shorthanded when he's on the ice. We really need speed from the 4th line (and throughout the lineup), even if they don't/can't do anything for offense. At this point, I'd even try to get Kapanen back and he's a dumbass.